Probiotics and Alzheimer’s disease what benefits of probiotics

It is estimated that the weight of the human brain is approximately equal to the weight of the gut. The human gastrointestinal tract is colonized from birth by trillions of microbes that regulate the healthy development of the central nervous system through neural, immune, and endocrine pathways. The interrelationship between the gut and the brain has been largely ignored; however, over the past decade, more and more attention has been paid to the role of the gut microbiota in regulating the gut-brain axis. Growing evidence suggests that there is a two-way communication between the brain and the gut, with gut microbes regulating central nervous system function bottom-up; in turn, the central nervous system exerts top-down regulation through The hypothalamic-pituitary-adrenal axis (HPA) shapes gut physiology and gut microbiota composition. what benefits of probiotics what benefits of probiotics
A growing body of research is beginning to reveal the interactions between the host, brain, and gut. Possible mechanisms of bidirectional communication along the gut-brain axis include: increased gut permeability allows gut microbes to enter the blood circulation; neurotransmitters (such as serotonin) and hormones (peptide YY) produced by gut microbes may affect host health; The vagus nerve is directly involved in the interaction between the enteric nervous system and the central nervous system; the inflammatory pathway of immune regulation is also involved in the gut-brain interaction; gut microbes can metabolize exogenous substances and affect nervous system function. what benefits of probiotics what benefits of probiotics
Although aging, family history, and susceptibility genes are considered important risk factors for Alzheimer’s disease, the rapid increase in Alzheimer’s disease incidence is not consistent with the Hardy-Weinberg equilibrium; therefore, we suggest that environmental factors may more important than genetic factors. Recent studies have shown that human commensal microbes are also very important environmental factors affecting host health. Gut microbes play major roles in human nutrition, digestion, neurotrophy, inflammation, growth, immunity, and protection from exogenous pathogens. Human disease states such as obesity, diabetes, hypertension, cirrhosis, autism, depression, and Parkinson’s disease are all related to the quantity and composition of gut microbes. However, research on Alzheimer’s disease and the gut microbiome is just beginning. Based on the existing epidemiological investigations on Alzheimer’s disease and the impact of gut microbiota on brain function and behavior and its role in the pathogenesis of some neurological diseases, we speculate that the pathogenesis of Alzheimer’s disease may also begin In the intestine, it is related to the imbalance of intestinal flora. what benefits of probiotics what benefits of probiotics
The gut-brain axis is a complex two-way communication network between the gut and the brain. In healthy people, the gut microbiota is usually stable and balanced, forming a mutualistic symbiotic relationship with the host. However, anything that disrupts or interferes with this relationship can lead to brain, digestive, and metabolic dysfunction. what benefits of probiotics what benefits of probiotics

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