The relationship between obesity and intestinal flora probiotics best kind

In the past 30 years, the rate of childhood obesity has increased sharply. According to WHO statistics, the incidence of childhood obesity has reached 20% in developed countries and is also increasing year by year in developing countries. Some scholars have found that the incidence of obesity in infants and young children is as high as 16%, and there is a strong correlation between infancy obesity and obesity at 2 years of age, indicating that obesity may begin in infancy, and then programmatically induce childhood obesity and increase adulthood. risk of obesity. In this study, the incidence of infant obesity at 1 year old was 18.5%, and 59% and 41% of infants with obesity at 1 year were overweight and obese at 6 months, respectively. However, the sample size of this study is limited and cannot be fully Represents the prevalence of obesity among infants in the region. probiotics best kind probiotics best kind
Current research has confirmed that obesity is often associated with diseases such as diabetes, hyperlipidemia, atherosclerosis, hypertension, heart disease, non-alcoholic steatohepatitis and cancer, so preventing childhood obesity is crucial. The etiology of obesity is complex. An accepted hypothesis is that obesity is the result of a combination of environmental, genetic, neurological and endocrine factors, and it is proposed that pathogens such as adenovirus 36 may also be involved in the pathogenesis of human obesity. Several studies have found that obese individuals have a dysbiosis of the intestinal flora, manifested by a decrease in Bacteroidetes, an increase in Firmicutes, or a decrease in the ratio of Bacteroidetes/Firmicutes. Kalliomaki et al. 12 followed up 49 children for weight, height and fecal microbiota abundance at 6 months, 12 months and 7 years after birth, and found that the number of Staphylococcus aureus in the feces of overweight children increased, while that of double The number of fidobacteria is low. Vael et al. found that higher BMI in preschool children was associated with higher intestinal concentrations of Bacteroides fragilis and lower staphylococcus concentrations. In the present study, both obese and overweight infants had lower intestinal bifidobacteria numbers than normal-weight infants, and low Bifidobacterium/E. coli values ​​were inversely associated with higher BMI, suggesting that obesity is associated with bifidobacteria numbers and intestinal bacterial community structure. A large number of laboratory and clinical studies are still needed to clarify the specific flora associated with obesity, and then provide a theoretical basis for early probiotic intervention to prevent obesity. probiotics best kind probiotics best kind
Some scholars have proposed that the intestinal flora may be involved in the pathogenesis of obesity as an “environmental factor”. Turnbaugh et al were the first to identify that obesity may be associated with differences in gut microbiota. In his study, he transplanted gut microbiota from obese mice (ob/ob) into germ-free mice, and the transplanted mice had increased fat mass, suggesting that the gut microbiota has the ability to increase energy intake from food in animals such as Backhead The experiment found that the intestinal flora regulates host lipid metabolism through fasting-induced adipocyte factor (Fiaf). The researchers transplanted the intestinal flora of ordinary mice to germ-free mice. Expression decreased, serum triglycerides increased, and body fat increased by 60%. Recent studies have found that high-fat diet can cause changes in gut microbiota and lead to metabolic endotoxemia and the resulting inflammation. probiotics best kind probiotics best kind

Leave a Comment

Your email address will not be published. Required fields are marked *