probiotics to prevent Clostridium difficile diarrhea probiotics c diff prevention

What is diarrhea caused by Clostridium difficile?

Antibiotics are one of the most commonly administered treatments in the world. Antibiotic medication may disrupt the usual balance of organisms in the gut. This can cause a variety of symptoms, the most common of which is diarrhea. probiotics c diff prevention

Clostridium difficile (C. difficile) is a harmful bacteria that can colonize the gut if the normal healthy balance is disrupted. Clostridium difficile infection, diarrhea, colitis, and pseudo-membranous colitis range from asymptomatic infection to toxic megacolon and death. Treatment is costly, and the financial impact on the medical system is significant. probiotics c diff prevention

What are probiotics, exactly?

Probiotics are living organisms that help the body to function properly (bacteria or yeast). It’s supposed to improve the balance of organisms in the gut, counteracting any disruptions in the gut microbial balance caused by antibiotic use, and reduce the likelihood of harmful bacterium colonization. probioticseverything.comprobiotics c diff prevention

Probiotics are present in nutritional supplements and yogurts, and pills are becoming more widely available in health food stores and supermarkets. Probiotics have been proposed as a means of both preventing and treating C. difficile-associated diarrhea as “functional food” or “good bacteria” (CDAD). probiotics c diff prevention

What exactly did the researchers look into?

The researchers looked into whether probiotics can help prevent CDAD in adults and children taking antibiotics, as well as whether they can cause harm (side effects). Up until March 21, 2017, the researchers conducted a thorough scan of the medical literature. probiotics c diff prevention

What did the scientists discover?

There are a total of 9955 participants in this review, which comprises 39 randomized trials. Thirty-one research (8672 people) looked at how helpful probiotics were at preventing CDAD in antibiotic users. probiotics c diff prevention

Our findings imply that taking probiotics with antibiotics reduces the chance of developing CDAD by 60% on average. The potential effect of probiotics is particularly obvious among trials enrolling participants at high risk of developing CDAD (> 5%), with a 70% risk decrease on average. probiotics c diff prevention

Our findings imply that taking probiotics does not raise the chance of developing adverse effects, since they were analyzed in 32 trials with a total of 8305 participants. Abdominal cramping, nausea, fever, loose stools, flatulence, and taste disturbance are the most common side effects observed in these investigations. probiotics c diff prevention

When administered in conjunction with antibiotics, probiotics appear to be safe and helpful in patients who are not immunocompromised or seriously debilitated. Despite the need for more research, hospitalized patients, especially those at high risk of CDAD, should be informed about the benefits and drawbacks of probiotics.

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