The relationship between obesity and intestinal flora probiotic drink

In the past 30 years, the rate of childhood obesity has increased sharply. According to WHO statistics, the incidence of childhood obesity has reached 20% in developed countries47, and it is also increasing year by year in developing countries. Some scholars have found that the incidence of obesity in infants and young children is as high as 16%, and there is a strong correlation between obesity in infancy and obesity at 2 years of age, indicating that obesity may begin in infancy, and then programmatically trigger childhood obesity and increase adulthood. risk of obesity. In this study, the incidence of infant obesity at the age of 1 was 18.5%, and 59% and 41% of the infants with obesity at the age of 1 were overweight and obese at 6 months, respectively. However, the sample size of this study is limited and cannot be completely Represents the prevalence of obesity among infants in the region. probiotic drink probiotic drink
Current studies have confirmed that obesity is often associated with diseases such as diabetes, hyperlipidemia, atherosclerosis, hypertension, heart disease, nonalcoholic steatohepatitis, and cancer [50], so preventing childhood obesity is crucial. probiotic drink probiotic drink
The etiology of obesity is complex. A generally accepted hypothesis is that obesity is the result of a combination of environmental, genetic, neurological and endocrine factors, and it is suggested that pathogens such as adenovirus 36 may also be involved in the pathogenesis of human obesity. Several studies have found that obese individuals have dysbiosis of intestinal flora, manifested as decreased Bacteroidetes, increased Firmicutes, or decreased Bacteroidetes/Firmicutes ratio. Kalliomaki et al. Weight-height and fecal microbiota abundance at 12 months, 12 months, and 7 years of age, and found that overweight children had increased numbers of S. aureus and lower numbers of bifidobacteria in their stool. A study by Vael et al40 found that higher BMI in preschool children was associated with higher intestinal concentrations of Bacteroides fragilis and lower staphylococcus concentrations. In this study, both obese and overweight infants had lower intestinal bifidobacteria numbers than normal-weight infants, and low bifidobacteria/E. group structure. A large number of laboratory and clinical studies are still needed to clarify the specific flora associated with obesity, and then provide a theoretical basis for early probiotic intervention to prevent obesity. probiotic drink probiotic drink
Some scholars have proposed that the gut microbiota may be involved in the pathogenesis of obesity as an “environmental factor”. Turnbaugh et al were the first to identify that obesity may be associated with differences in gut microbiota. In his study, he transplanted gut microbiota from obese mice (ob/ob) into germ-free mice, and the transplanted mice had increased fat mass, suggesting that the gut microbiota has the ability to increase energy uptake from food. Animal experiments by Backhead and others found that the intestinal flora regulates host lipid metabolism through fasting-induced adipocyte factor (Fiaf). The researchers transplanted the intestinal flora of ordinary mice into germ-free mice. Intestinal Fiaf expression decreased, serum triglycerides increased, and body fat increased by 60%. Recent studies have found that a high-fat diet can induce changes in the gut microbiota, leading to metabolic endotoxemia55 and the resulting inflammation. probiotic drink probiotic drink

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