Multiple sclerosis (MS) is an autoimmune illness in which the immune system assaults myelin, the waxy coating on nerves, by mistake. Myelin serves a variety of functions, including nerve protection and transmission speed. Communication between the brain and the rest of the body is severely hampered without it. probioticseverything.com p. histicola probiotic
Numbness or weakness, double vision, slurred speech, lack of coordination, difficulty walking, and, in rare cases, paralysis are all symptoms of the illness. Symptoms appear in waves, becoming more severe during an episode and then diminishing.
There is presently no cure for MS; instead, treatments try to improve recovery time, manage symptoms, and decrease disease progression. probioticseverything.com p. histicola probiotic
MS and gut bacteria
A large number of microorganisms live in the human stomach. In fact, scientists believe that there are as many bacteria in our bellies as there are cells in our bodiesTrusted Source. Our microscopic passengers have become an important element of our body’s normal functioning over time, but the extent to which they influence our health and disease is yet unknown.
Autoimmune illnesses are starting to become an issue in developed countries, and as a result, they have gotten a lot of attention in recent years. The importance of gut microorganisms is particularly intriguing. probioticseverything.com p. histicola probiotic
The cause for the difference in gut flora in industrialized countries is uncertain, however it could be attributable to a variety of factors, including reduced parasite exposure, the Western diet, or increased antibiotic use. probioticseverything.com p. histicola probiotic
Because MS is characterized by an aggressive immune attack on myelin, scientists have pondered if changing the microbiota could affect disease development. Is it feasible to introduce a bacteria strain or a probiotic that will alter the microbiome and alleviate MS symptoms?
To find an explanation, a team of researchers from the Rochester, Minnesota-based Mayo Clinic looked into three different types of microbes. They investigated bacteria cultivated from the human intestine on a mouse model of MS. probioticseverything.com p. histicola probiotic
MS with Prevotella histicola
One of the three bacteria strains, Prevotella histicola, successfully inhibited MS in mice. P. histicola, in particular, caused a decrease in two cell types that promote inflammation, known as pro-inflammatory cytokines. probioticseverything.com p. histicola probiotic
Conversely, it raised the number of disease-fighting cells such as dendritic cells, T cells, and a type of macrophage. Overall, inflammation and demyelination were reduced, which excites but concerns the researchers. probioticseverything.com p. histicola probiotic
Bugs as medications, dubbed “brugs” by Dr. Murray, would be a tremendous step forward in medicine. It would be game-changing to be able to treat an illness as complex as MS in such a simple and reasonably cost-effective manner.
The new findings are consistent with those of other recent studies in the same vein – for example, studies of MS patients’ microbiomes have discovered reduced amounts of bacteria in the Prevotella genus. Prevotella levels have also been reported to rise in MS patients who are on anti-inflammatories. probioticseverything.com p. histicola probiotic
Another interesting parallel is that Western diets foster an abundance of Bacteroides, whereas a high-fiber agricultural, or cereal-based, diet appears to promote greater levels of Prevotella, pointing to yet another trail of clues to follow.
Although the study focused on MS, the findings have a far broader application. “It’s not just for MS,” says first research author Ashutosh Mangalam, Ph.D., of the University of Iowa Carver College of Medicine in Iowa City. “This may have a similar moderating effect on other nervous system and autoimmune illnesses.”
Gut bacteria are in the limelight across the board, and their function in health and disease is under ongoing scientific study. More work will be required, as always, but given the tremendous level of interest and the potential for significant advances, that work is expected to be completed soon. probioticseverything.com