Gut microbiota and obesity probiotics for kids

The normal intestinal flora mainly maintains the health of the host through many physiological functions, such as resisting the invasion of pathogenic microorganisms, inhibiting their growth and reproduction, having immune regulation and promoting the synthesis and absorption of nutrients. Infancy is the period of the fastest physical growth and development, and the interaction of normal gut microbiota and nutrient metabolism is crucial to the growth and development of children. probiotics for kids probiotics for kids
Studies have shown that the gut microbiota is not only involved in cholesterol and lipid metabolism, but also affects the oligosaccharides (oligofructose, inulin, etc.) and polysaccharides (resistant starch, cellulose, hemicellulose, pectin, etc.) ) and protein for glycolysis to produce short chain fatty acids (SCFAS) such as acetic acid, propionic acid and butyric acid, which provide nutrients and energy for the growth and reproduction of normal intestinal flora, and can adjust intestinal pH and maintain intestinal mucosal cells. structural integrity. Oin et al. found that the human gut metagenome contains genes that degrade complex polysaccharides and synthesize short-chain fatty acids, essential amino acids, and vitamins, indicating that the gut microbiota is involved in the metabolism of nutrients in the host. probiotics for kids probiotics for kids
Previous studies have confirmed that the distal gut microbiota of genetically obese (ob/ob) mice contains genes related to energy intake and participates in lipid and carbohydrate metabolism in vivo. Pang et al. used the human flora-associated HFA piglet model to anthropomorphize and transplanted the intestinal flora of a healthy 10-year-old boy into sterile pigs, confirming that the intestinal flora is involved in the process of metabolism and nutrient metabolism in vivo, and proposed that Changes in the quality and quantity of gut microbiota are associated with obesity. probiotics for kids probiotics for kids
A study by Ley et al.9 found that the number of Bacteroides in the intestine of obese people decreased, and the proportion of Bacteroidetes increased significantly after one year of low-calorie diet, and the body weight decreased, suggesting that maintaining normal intestinal flora structure has a potential therapeutic effect on obesity. Murphy’s animal studies suggest that the structure of intestinal flora in obese model mice has nothing to do with energy intake. At present, a number of studies have confirmed that the interaction of normal intestinal flora and intestinal nutrients affects the host energy metabolism, providing a theoretical basis for the prevention and treatment of obesity. probiotics for kids probiotics for kids

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