Problems faced by probiotics in tumor prevention and treatment probiotics uses

It should be noted that, in addition to positive effects, probiotics can sometimes have negative effects. For example, Bifidobacterium and others regulate natural immune defense mechanisms to fight cancer by activating NK cells. Human studies have shown that peripheral blood NK cells with moderate to high cytotoxic activity can reduce the risk of epilepsy, while low activity of NK cells can increase the risk of cancer. probiotics uses probiotics uses
The safety issues of probiotics have recently begun to receive attention, including: pathogenicity and infectivity; harmful metabolic activities (such as excessive dissociation of bile salts or degrading mucosal detrimental to human health); possible gene transfer leading to the development of antibiotics resistance; excessive immune response, etc. Moreover, the human body and microorganisms are a complex ecosystem, which is jointly shaped and maintained by different host and microbial factors. The changes in the distribution and composition of microorganisms in the body may affect the physiological and immune functions of the body. Probiotics must be carefully evaluated for toxicity and metabolic effects before clinical application to ensure that their quality and safety meet certain standards. probiotics uses probiotics uses
In addition, tumor formation and treatment can also affect the probiotics in the body. The use of carcinogens has been reported to enhance the activity of NK cells and the function of T lymphocytes to reduce the ability of LcS to modulate the host immune response. Intestinal irrigation before tumor resection will cause the loss of mucus and epithelial cells, which will affect normal peristalsis and other functions, resulting in the ineffective colonization of probiotics. In recent years, great progress has been made in the research on probiotic preparations. Commonly used probiotic preparations, such as Bifikang Meichangan Jin Bifid, have the functions of improving immunity, regulating intestinal flora, promoting gastrointestinal function and adjuvant treatment of liver diseases. However, there are still many problems in practical production and application, such as the emergence of drug-resistant strains that are difficult to colonize the intestinal tract, the inappropriate use of antibiotics in combination with a short shelf life at room temperature, and the poor stability of viable bacterial counts. probiotics uses probiotics uses
The efficacy of probiotics in the prevention and treatment of tumors remains to be further studied. In the future, through well-designed clinical trials, the mechanism of action can be analyzed in detail and the molecular and cellular mechanisms of tumor pathogenesis and the effect of probiotics can be developed. Elucidating the molecular mechanism of the action of probiotics in vivo will help to comprehensively understand them, identify and select the most effective bacterial species for tumor treatment, and determine the optimal dose to improve the therapeutic effect and utilization of probiotics. Although there is still a long way to go to achieve this goal, through continuous in-depth research, more and more effective probiotic anti-tumor drugs will be developed to provide new treatment options for tumor patients. probiotics uses probiotics uses

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